DISEASES

Influence of endometriosis on embryo implantation and methods to improve this condition

Author: Dr. Lee
Clicks:
Time: 2014/7/5 10:07:00

The process of embryo implantation, which includes orientation, adhesion and invasion, is complex. It requires the synchronization, interaction and cooperation of emdometrium and embryo. At present, the mechanism has not been fully elucidated, but the success factors of embryo implantation are clear. It requires high quality embryos, receptive endometrium and suitable endocrine environment. And this document generally introduces the influence of endometriosis on embryo implantation, and methods to improve the embryo implantation rate of the endometriosis sufferers.


1. The influence of endometriosis on embryo implantation


1) Impacts on oocytes and embryo quality


The study has found that, if the donated oocytes are from endometriosis patients, the recipients will have a decreased pregnancy rate and implantation rate. It is obvious that this is caused by affected oocytes and embryos. Peritoneal fluid flows into the fallopian tubes and uterine cavity, playing an important role in the stability of the environment for embryo growth. So the change of peritoneal fluid composition can directly act on the embryo, causing its development retardation and even death.


Studies have also shown that the endometrium can induce inflammation in the abdominal cavity, increasing the quantity of macrophage, many cytokines, prostaglandins and adhesion molecules. And some of these increased contents will be toxicant to embryo.


2) Impacts on the endometrial receptivity


The endometriosis patients will have an increased level of prostaglandins. And this stimulates the uterine contractions. It is estimated that the contraction of endometriosis patients is three times than that of the normal females. Once the uterine contraction varies, the sperm conveying and embryo implantation will be affected, declining the ability of getting pregnant.


2. Methods to improve the embryo implantation rate of the endometriosis sufferers


1) The application of GnRH-a


Up to now, it is only a long-time use of GnRH-a that works. Adoption of GnRH-a for 3 to 6 months before IVF will increase about four times of pregnancy rate.


2) Anti-inflammatory therapy


The NSAIDS can inhibit the production of prostaglandins. Through lessening the uterine contraction, NSAIDS increases the success rate of embryo implantation.


3) TCM treatment


Patients can take patent medicine Fuyan Pill. Fuyan pill can promote blood circulation, nourish spleen and eliminate pathogens like bacteria, virus and chlamydia. This method has been accepted by more and more patients for its effectiveness, safety, low recurrence rate and no side effects. More important, endometriosis patients can be cured through this treatment. There is no need to have an IVF.


4) Surgical treatment


It has been proved that surgeries can treat endometriosis and improve the natural conception of endometriosis patients. Surgery removes the lesions in the surface of abdominal cavity and pelvic cavity. In this way, it can improve the virulent environment in pelvic cavity, reducing the growth chance of lesions in the process of ovulation induction.