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Influence of Novel Coronavirus on Digestive System

Author: John
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Time: 2020/2/9 11:09:05

On the evening of February 1, Shenzhen No.3 People's hospital held a press conference to announce the latest findings. The Institute of Hepatology of Shenzhen No.3 People's hospital found that the nucleic acid of 2019-nCoV was positive in the feces of some patients diagnosed with pneumonia infected with 2019-nCoV, which may indicate the existence of the live virus in the feces. At present, researchers are doing further research on virus isolation.

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Therefore, Liu Yingxia, vice president of the hospital, said that people should be reminded to wash their hands and pay attention to personal hygiene while wearing masks. It is worth noting that 2019-nCoV has also been indicated in the feces of confirmed patients. 

On January 31, the authoritative medical journal New England Journal of Medicine (NEJM) published the research paper "first case of 2019-nCoV in the United States" online. The paper also noted that the first confirmed 2019-nCoV patient in the United States developed diarrhea and abdominal discomfort on the second day after hospitalization.

In the stool samples of diarrhea, doctors in the United States also detected the presence of 2019 ncov (positive results of RRT PCR). In this regard, the authors also stressed that the potential impact of the virus on an extra respiratory tract is not well understood.

On the same day, the People's Hospital of Wuhan University and the Wuhan Virus Research Institute of the Chinese Academy of Sciences also observed that the first symptom of some patients with new coronavirus pneumonia was only diarrhea, and it was suspected that the digestive system might also be the transmission route of new coronavirus. After that, the virus nucleic acid was also found in the stool and anal swabs of these patients.

According to the research team, on the basis of droplet transmission and contact transmission proposed in the previous national authoritative guidelines, there is still a certain fecal-oral transmission of the new coronavirus. Clinicians, especially digestive physicians, should pay close attention to the atypical symptoms of new crown pneumonia, and do a good job in personal protection for patients' vomitus and feces.

Diarrhea has long been a symptom of the diagnosed population. A study was published in the lancet, a top medical journal, on January 30 by the front-line clinical workers and experts from Ruijin Hospital Affiliated to Shanghai Jiaotong University School of medicine and Wuhan Institute of Virology, Chinese Academy of Sciences.

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In the study of 99 patients in Wuhan Jinyintan hospital, 83% of them had a fever and 82% had a cough. These two are the most common clinical features. But patients will also have other rare symptoms, including diarrhea in 2% of patients. In fact, scientists' research on coronaviruses shows that they are related to a variety of diseases in humans and animals. Besides the respiratory system, they can also cause digestive and nervous system diseases.

In addition, it is worth mentioning that the studies of Hao Pei and Shi Zhengli of Shanghai Pasteur Institute of Chinese Academy of Sciences and Wuhan Institute of viruses of Chinese Academy of Sciences show that, like SARS virus, S protein of 2019-nCoV mainly binds to a protein called ACE 2 on the surface of human cells.

The epithelial cells of human lung and small intestine are rich in ACE2. However, according to previous studies on the SARS virus, the SARS virus only damages lung cells but rarely invades intestinal cells. However, the Middle East respiratory syndrome-associated coronavirus (MERs), with a mortality rate of 35%, causes not only respiratory symptoms, but also gastrointestinal symptoms such as diarrhea, and even affects the sports system.

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