The Substance in Coffee Can Inhibit the Growth of Prostate Cancer Cells

Author: John
Time: 2019/12/20 15:51:53


Coffee is one of the most popular drinks on the earth, and it is also called a complex cocktail. Its ingredients are complex, which contains not only more than 1000 non-volatile compounds, but also more than 1500 volatile compounds. There are also significant differences in the types and contents of the compounds in each kind of coffee, which is mainly related to how coffee manufacturers prepare coffee beans.

How do drinks with so many active ingredients that are widely consumed by people all over the world affect your health?

Recent research on coffee has focused on the relationship between coffee and the reduction of prostate cancer risk. With the increasing number of such studies, people pay more attention to the relationship between them. Scientists are studying the compounds in coffee to see how their components fight cancer cell growth.

Prostate cancer is one of the main causes of cancer death in men. If the substances in coffee can help reduce the risk of this cancer, it will be of great significance. Recently, researchers at the Graduate School of medicine, Kanazawa University, Japan, tested a series of coffee compounds for prostate cancer in mice, and they used cancer cells that are resistant to standard anticancer drugs.

Initially, scientists studied six coffee compounds, and then they narrowed their attention to caffeinol acetate and caffeinol, both of them are naturally compounded in Arabica coffee. In cell experiments, scientists found that when they added caffeinol acetate and caffeinol to prostate cancer cells in a culture dish, the cancer cells did not grow so fast.

Next, they tested the effects of two coffee compounds on prostate cancer cells transplanted into mice. They used 16 mice: 4 mice in the control group without any treatment; 4 mice in the caffeinol acetate treatment group only with caffeinol acetate treatment; 4 mice in the caffeinol acetate treatment group only with caffeinol; and 4 mice in the final group with caffeinol acetate combined with caffeinol.

The researchers found that caffeinol acetate and caffeinol can inhibit the growth of cancer cells in mice, but the combination seems to have a synergistic effect, making tumor growth significantly slower than untreated mice. After 11 days of treatment, untreated tumors grew to 3.5 times the original volume (342%), while mice treated with two coffee compounds grew about 1.5 times the original volume (167%).

In December 2018, researchers published the results in the journal of the prostate.

More needs to be done

Although scientists have seen the inhibitory effect of coffee on prostate cancer cells in mouse experiments and cell research, it is still too early to confirm that coffee can treat prostate cancer. At present, it is not clear whether the acetic acid and caffeinol have been removed in the process of brewing or filtering the coffee people drink.

Scientists have planned to expand their work by first considering how to test the findings in larger samples, then in humans.

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